Combination chemotherapy for metastatic colorectal cancer
نویسندگان
چکیده
منابع مشابه
Metastatic colorectal cancer: integrating irinotecan into combination and sequential chemotherapy.
The chemotherapy of metastatic colorectal cancer (CRC) has undergone a succession of refinements. Through the biochemical modulation of 5-fluorouracil (5-FU) with folinic acid (FA), the use of infusional rather than bolus regimens and the combination of 5-FU/FA with other active agents (notably irinotecan), first-line response rates (RRs) of 40% can be achieved, with patients surviving up to 17...
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Colorectal cancer (CRC) is the fourth most common malignancy in the United States (1). Approximately 130,000 new patients will be diagnosed with this cancer in 1999. It is the second leading cause of cancer death, with 55,000 patients expected to die of it. Most patients die of metastatic disease. The vast majority of them have liver as the dominant site of metastases (2). Approximately 30% of ...
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The combination of oxaliplatin or irinotecan with bolus and infusional fluorouracil (FU) and folinic acid (FA) is considered the standard regimen for the first-line treatment of metastatic colorectal cancer [1–4]. However, this regimen is inconvenient owing to its requirement for continuous infusion of FU via vascular access. To overcome this drawback, oral fluoropyrimidines such as capecitabin...
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Toxicities commonly associated with antiangiogenic agents include hypertension, proteinuria, wound-healing complications, bleeding or hemorrhage, thromboembolic events, hypersensitivity reactions, and gastrointestinal perforation; however, toxicities most often attributed to chemotherapy include nausea, vomiting, diarrhea, constipation, fatigue, neuropathy, mucositis, hand-foot syndrome, hypers...
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ژورنال
عنوان ژورنال: Arhiv za onkologiju
سال: 2003
ISSN: 0354-7310,1450-9520
DOI: 10.2298/aoo0303155k